Hesselberth Lab

We are an RNA biology and technology development lab at the University of Colorado Anschutz Medical Campus.

RNA damage and repair

Like DNA repair systems that surveil and repair genome damage to preserve the genetic code, the products of RNA damage are substrates for coupled end modification and processing steps. But unlike our deep under-standing of the DNA damage response, we are only beginning to learn how RNA damage, end modification, and processing are integrated in the RNA damage response to orchestrate RNA processing for regulatory control.

Single-cell technology development

We develop new molecular and computational approaches to advance single-cell analysis including approaches to measure biochemical activities, to understand molecular dissemination in vivo, and to improve the analysis of cell-type-specific gene expression patterns.


Open positions in single-cell tech dev

We are hiring postdoctoral research associates and professional research assistants to support our work in single-cell technology development. Wed lab recently developed two new single-cell approaches to measure biochemical activities in single cells and to track DNA conjugates through tissues.

NIH Transformative R01

We were awarded the NIH Directors' Transformative Research Award to develop new approaches to measure biochemical activities at cellular resolution. This award stems from the hard work of Mandy Richer, who worked out the approach to measure activities of DNA repair enzymes in cells.

Lab Members

Principal Investigator


Jay Hesselberth, PhD

Associate Professor

Research Scientists


Kent Riemondy, PhD

RNA Bioscience Initiative

Graduate Students

Postdoctoral Fellows

Research Assistants

Joining the lab

Postdoctoral Fellows

Prospective postdoctoral candidates should submit a CV, a description of their past and future research interests, and the names and contact information for at least two references.

Graduate Students

The Hesselberth lab accepts graduate students from the Molecular Biology and Biomedical Sciences Programs.